CODOTAB

CODOTAB binds to the opioid receptors μ, κ, δ (mu, kappa, delta respectively), distributed widely in the central and peripheral nervous system and inhibits the transmission of the pain impulse in the nociceptive afferent neurons. Moreover, CODOTAB shows its analgesic effect profoundly via morphine which binds highly with mu receptor as 10% of codeine is metabolized into morphine. In addition, CODOTAB suppresses cough by direct action in cough center present in the medulla.