It inhibits reabsorption of Na+, Cl- and K+. Spironolactone is a specific antagonist of aldosterone. It increases Na and water excretion but retains K+. Thus it acts both as diuretic and an antihypertensive. It reduces oedema and counteracts secondary aldosteronism caused by vol depletion Na loss. K loss is reduced. It is used in the treatment of Hypertension, Liver Cirrhosis with Ascitis due to liver cirrhosis, Congestive Heart Failure. Edema associated with heart failure, renal impairment and nephritic syndrome.
