It is a prodrug. The nitro group of GAT is reduced in protozoa forming free nitro radical, which covalently binds to protozoal DNA. This leads to DNA damage and then cell death. It is used in the treatment of Intestinal Amoebiasis, Giardiasis, Trichomoniasis, Acute Necrotizing Ulcerative Gingivitis, Bacterial Vaginosis, Anaerobic Bacterial Infections and prevention of Post-operative Anaerobic Bacterial Infections and eradication of H. pylori in Peptic Ulcer Disease.
